Control strategies in bioreactor systemsFuture directions Bioprocessing is an umbrella term that describes the research, development, manufacturing, and commercialization of products derived from or used by biological systems. For industrial purposes, bioprocessing is widely incorporated into pharmaceutical, nutraceutical, food, and beverage production processes.
Other cell culture projects, such as those that rely on immobilized cells, may rely on fluidized bed bioreactors, in which media passes through the distributor to the cells. Within this system, velocity allows media to reach, subsequently suspend, and mix with the cells. Since their initial development in the 1970s, distributed control strategies have enabled various advanced process control strategies to be controlled within a single framework. DCSs allow operators to supervise and control an entire industrial plant from a centralized control station while simultaneously gathering and storing data for control and process analytics.
Impeller speed can also be controlled and closely monitored in both single- and multiple-impeller bioreactors. Tachometers, for example, can be installed into bioreactors to sense whether desired impeller speeds are within the optimal range3. Importantly, uneven shear characteristics or energy dissipation of impellers can lead to the destruction of cells and microorganisms.
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