Bootstrapping gear for coronavirus tests: How companies innovated to solve a critical shortage

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The NP swabs are not your typical Q-tip. All these requirements make manufacturing NP swabs complicated. Origin, a California-based 3D printing company, was one of the four manufacturers whose swab prototype was clinically validated by Arnaout’s team.

During the first few months of the American coronavirus outbreak, the country experienced an acute shortage of test kits and related equipment — the supplies needed to track the spread of the virus and trace infected individuals.

The NP swabs are not your typical Q-tip. They are usually a 15-centimeter plastic stick, with a head that's about a centimeter and a half long and 3 millimeters wide. The neck of the swab is a little narrower, flexible and usually coated with a velvet-like material called flock, which allows efficient collection of the virus from deep in the upper respiratory passage.

“The beauty of 3D printing is that the time between a development of a design and a prototype in hand is a matter of hours. So you can get on a computer and you can draw on a computer the shape of the swab … and then you hit ‘enter,’ and it sends that design to a printer, and it is printed out just like that. … And if you look at it and decide it doesn’t work for you, you can change the design and get a new prototype back in again, in a matter of hours.

While successful clinical trials are not necessarily required to sell this type of product, NP swabs are still a medical device, and Arnaout says their manufacture “should be taken seriously.” But swabs were not the only component of COVID-19 testing kits in short supply. Worldwide supplies of VTM were also severely disrupted. This too motivated many scientists, chemists and companies to come up with innovative solutions.

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