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The world’s first “human challenge” trial in which volunteers were deliberately exposed to COVID19 to advance research into the disease was found to be safe in healthy young adults, leaders of the study said on Wednesday.

into the disease was found to be safe in healthy young adults, leaders of the study said on Wednesday.

Open Orphan is running the project, launched last February, with Imperial College London, Britain’s vaccines task force and Orphan’s clinical company . The Imperial trial exposed 36 healthy male and female volunteers aged 18-29 years to the original SARS-CoV-2 strain of the virus and monitored them in a quarantined setting. They will be followed up for 12 months after discharge.

“People in this age group are believed to be major drivers of the pandemic and these studies, which are representative of mild infection, allow detailed investigation of the factors responsible for infection and pandemic spread,” said Chris Chiu, chief investigator on the trial and professor of infectious diseases at Imperial.

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