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Patients with monkeypox in the UK have noticeably different symptoms from those seen in previous outbreaks, according to researchers in London, raising concerns cases are being missed.

Patients reported less fever and tiredness and more skin lesions in their genital and anal areas than typically seen in monkeypox, the study of 54 patients at London sexual health clinics in May this year found.

Cases have also risen in the countries where it more usually spreads, according to the World Health Organisation. The authors, from a number of institutions including Chelsea & Westminster Hospital NHS Foundation Trust, said case definitions should be reviewed to avoid cases being overlooked, particularly as monkeypox can “mimic” other common sexually transmitted infections like herpes and syphilis.

“Misdiagnosis of the infection may prevent the opportunity for appropriate intervention and prevention of onward transmission,” said Dr Ruth Byrne, from the trust.

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