5 things to know before the stock market opens Wednesday

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Here are five key things investors need to know to start the trading day.

McDonald's shares tanked after an E. coli outbreak at the chain killed 1 person and hospitalized 10 others.

The IRS raised federal income and capital gains tax bracket thresholds, while also boosting estate and gift tax exemptions.Stock futures slid Wednesday after the S&P 500 posted its first back-to-back loss since early September. Futures tied to thefell 0.2%. The yield on the benchmark 10-year Treasury note rose 3 basis points to 4.

. The agency said 49 cases had been reported in 10 states between Sept. 27 and Oct. 11, with most of the illnesses in Colorado and Nebraska. An older adult in Colorado died while 10 others were hospitalized. Initial findings from the ongoing investigation show that some of the illnesses may be linked to slivered onions that are used in the Quarter Pounder and sourced by a single supplier that serves three distribution centers, according to a statement from McDonald's.

— CNBC's Pia Singh, Leslie Josephs, Annika Kim Constantino, Jacob Pramuk, Kate Dore and Amelia Lucas contributed to this report.

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