With Launch Of New CRISPR Company, Competition Extends To Diagnostics

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One of Sherlock Biosciences’ key technologies comes from the Broad Institute lab of Feng Zhang, who did some of the early work elucidating the DNA-modifying potential of CRISPR and its associated enzymes after their discovery in bacteria.

licensed from the University of California, Berkeley, that was developed in the lab of early CRISPR researcher Jennifer Doudna, raised $23 million from investors including Mayfield, 8VC and Apple CEO Tim Cook.

Sherlock Biosciences cofounders Omar Abudayyeh, Jonathan Gootenberg, Rahul K. Dhanda, James J. Collins, and Pardis Sabeti.Omar Abudayyeh and Jonathan Gootenberg, also Sherlock cofounders, developed the company’s eponymous technology in Zhang’s lab collaborating with Collins.

Sherlock Biosciences has also licensed another technology it’s calling INSPECTR, which recognizes DNA or RNA in the same way as SHERLOCK, but has a different mechanism to signal a hit. When the system matches with the DNA or RNA sequence it’s looking for, it’s like two pieces of a puzzle coming together, says Collins, who developed the system: “It now allows that puzzle to become a machine that will make a protein,” reporting detection.

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