This overlooked corner of women's health could be a $350 billion market opportunity

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Menopause is among the female health conditions with the highest unmet need and has 'enormous potential for innovative treatments,' according to McKinsey.

Celebrities from Drew Barrymore to Naomi Watts have opened up about symptoms and promoted products. Yet despite the increased chatter, there is a long way to go when it comes to treating symptoms — and a lot of opportunities for companies to step in to fill the gap.

Menopause occurs when women have gone 12 consecutive months without a menstrual period. While that happens, on average, at around age 51, women can have symptoms for years beforehand in what's known as perimenopause. Symptoms can also continue in the postmenopausal phase. "Our knowledge has changed," said Dr. Karen Adams, a Stanford University professor and director of the school's menopause and healthy aging program. "It is really very exciting, but women are left shaking the trees trying to find someone who can help them.", which has a number of products in its portfolio. They include Duavee and Premarin, hormone therapy treatments for hot flashes and the prevention of osteoporosis., which has a market cap just north of $400 million.

"It gives you that consistent amount of delivery, and ... there's no concern about compliance and if you'll remember a day or forget a day," he said. "What it means in the end is that you feel better.", which has an even smaller market cap of about $47 million, has a hormone therapy in the pipeline.

Midi Health, the other Progyny partner that's a virtual care clinic specializing in perimenopause and menopause, is another company attracting investor dollars. In September,Still, women's health has long been underfunded, and menopause is getting just a small slice of that pie.

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