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From COVID-19 to cancer: BioNTech CEO wants to get company back to its roots

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He has conquered Covid for the time being, and now the CEO of BioNTech says he wants to turn his attention back to his first interest: cancer. Dr. Ugur Sahin is trying out the same mRNA technology that underlies the COVID-19 vaccine that BioNTech brought to much of the world -- along with its partner Pfizer -- to try to improve the newest and riskiest approach to treating cancer: CAR-T therapy.

He has conquered COVID-19 for the time being, and now the CEO of BioNTech says he wants to turn his attention back to his first interest: cancer.

"We are cancer doctors," Sahin told CNN in an interview ahead of the meeting. "We are really passionate about that. What we want to accomplish is to provide really better treatments." They work best against blood-based cancers, Sahin noted. He is trying the approach against solid tumors. BioNTech is looking at a particular molecule active on cancer cells called claudin 6. "It is not expressed in healthy cells," Sahin said. "But it is activated and expressed in several types of cancers like testicular cancer, ovarian cancer, endometrial cancer, and the percentage of other tumors, a smaller percentage of stomach cancer, lung cancer and of some sorts of sarcomas," he added.

"This appears to be safe. We don't see toxicity. But we see a clinical activity. We see, even at the low dose, we are starting to see shrinkage of tumors."

 

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