Insulin icodec has been submitted for regulatory review in the United States, Canada, Europe, China, Australia, Switzerland, and Brazil, with decisions anticipated starting in the first half of 2024.
In ONWARDS 1, in contrast, sulfonylureas and glinides were stopped at the time of randomization."That's not definitive, but I would argue that's the explanation, to be proven by formal testing." The percentage of time in blood glucose range was also significantly higher with icodec than glargine , also confirming superiority.
ONWARDS 3 randomized 588 patients each to once-weekly insulin icodec plus once-weekly placebo or once-daily
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