European stocks head for lower open as sentiment sours slightly; Novo Nordisk to start session as Europe's most valuable firm

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European markets are heading for a negative open Tuesday as sentiment gradually soured in Monday’s trading session.

Data releases Tuesday include final purchasing manager's index data, measuring business activity in the manufacturing and services industry, from the euro zone and U.K. for August.UBS has downgraded two large global automakers over mounting competition from Chinese electric vehicle manufacturers.

"August was a tough month for investors," said Mark Haefele, global wealth management chief investment officer at UBS, noting that the S&P 500 ended last month down 1.6%."Contradictory evidence and conflicting interpretations of economic data, asset pricing, and the outlook for Fed policy have buffeted asset prices in recent weeks as expectations of a soft landing for the US economy have ebbed and flowed.

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