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Many of those CVs would have been perfect for applying to larger companies, but just as your chances of success increase when you tailor your CV to a role, they will also grow when you tailor it to a company. This is because any application to a large entity is likely to go first to a human-resources department , where it’ll get processed in a certain way, often being compared to the job description or checked for certain key words.
Unfortunately it has to get past the HR software first. A small ad for a lab tech got me 500 applications. I had to use the software to eliminate 450.