$11 billion drugmaker Mylan and US drug giant Pfizer are teaming up to reshape Mylan’s business. 3 tough questions from Wall Street analyst show the challenging road ahead.

Three tough questions from Wall Street analysts on a Monday conference call show why the spinoff could face an uphill battle.

A major deal announced on Monday will combine generic drugmaker Mylan with a unit of Pfizer that makes off-patent products like Viagra., best known for making the EpiPen allergy shot. Mylan's shares have lost almost half their value over the past year, though they surged 14% on Monday after the deal was announced. Pfizer's stock fell 2%.

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