vaccinated in research trials and use them to make treatments for the deadly viral infection.Ebola and other newly emerging deadly diseasesThe technique, based on people exposed to the Ebola vaccine but not the Ebola virus itself, suggests protective therapies could be developed from people who are disease-free.
He noted that besides Ebola, many experimental vaccines for other life-threatening infections, such as H5N1 and H7N9 bird flu and Middle East Respiratory Syndrome , are entering clinical trials and could offer similar opportunities for antibodies to be collected. The largest Ebola epidemic in history swept through Sierra Leone, Liberia and Guinea in 2013-2016, killing more than 11,000 people. That outbreak prompted a global push to develop vaccines and treatments – and some, including a protective shot developed by Merck and several antibody therapies for infected patients, have been deployed in the Congo outbreak.
The Oxford team decided to try using blood from trial volunteers who had been given an experimental Ebola vaccine and whose immune system had responded to the shot by making antibodies. They successfully isolated 82 antibodies taken from 11 volunteers in trial at Oxford’s Jenner Institute.
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