This story is available exclusively to Business Insider subscribers.Little-known biotech firm BioNTech made headlines after the long-awaited phase three data for its vaccine with Pfizer arrived, indicating the first effective coronavirus shot.showed the vaccination worked for 90% of all study participants, exceeding the requirements for approval by the US FDA.
As well as being chief physician for infectious diseases and tropical medicine, Wendtner is the head of the special unit for highly contagious life-threatening infections at the Munich Clinic Schwabing.A rate of 90% is remarkable — many ongoing vaccination studies on Covid-19 currently only require a success rate of at least 50%. This is also the prerequisite for approval by the US FDA. BioNTech and Pfizer are now in the process of applying to the FDA for emergency approval.
Clinical tests were also carried out on a very large scale. It was clear that, even if we could produce a possible vaccine within just a few weeks, clinical tests would take a while as we had to give the vaccine to tens of thousands of people.You need partners at your side for large projects like this — that's why we decided to work with our colleagues at Pfizer.
We called it project "Lightspeed" to make it clear that we're not wasting any time. It was thanks to having a like-minded partner like Pfizer that it was possible to keep the development time so short. For common vaccines you have to grow viruses in the laboratory and then infect cells with these viruses in huge cell cultures, for which you need very large units. And the process that follows is very, very laborious. Only large-scale companies can do that. To put it simply, for an mRNA vaccine I initially only need a 50-liter bioreactor with which I can produce the mRNA. That's the great thing because it's very scalable. The production goes overnight.
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