Belgium’s Royale Union Saint-Gilloise progressed as Group D winners with a 2-0 victory against Malmo, while Bundesliga leaders Union Berlin beat Braga 1-0 to move above them into second spot, two points ahead of the Portuguese side.
PSV had two first-half efforts chalked off for offside but took a deserved lead through Joey Veerman in the 55th minute when he clipped a left-footed effort past Aaron Ramsdale before substitute Luuk De Jong made it two with a header moments later. Sergej Milinkovic-Savic and Pedro were on target for Lazio as they came from behind to see off Midtjylland and move to eight points from five games in Group F, three ahead of Feyenoord and SK Sturm Graz who meet later on Thursday.