3Brain is a Swiss company focusing on the development of next-generation therapeutics for the treatment of brain disorders, and CSEM is a Swiss private, non-profit research and technology organization with more than 35 years of Deep Tech development experience.Newly produced chip will make imaging easier.
The company also suggests that cell-electronic interfaces like patch clamps and, more recently, high-density multi-electrode arrays are limited to 2D and suffer many limitations when it comes to measuring 3D model systems like brain organoids or tissues. 3Brain worked to develop a cell-electronic interface based on complementary metal-oxide semiconductor technology in order to overcome these challenges.The 3D CMOS microchip is equipped with sensory gold-electrodes mounted on thousands of biopolymer-covered microneedles.
Mauro Gandolfo, CEO and co-founder of 3Brain AG, said: “What we really want is to empower researchers to ask new and daring biological questions that have so far been impossible to investigate. “Our cell-electronic interfaces expand the concept of optics-free functional imaging, all without the need for biological markers, fluorescent proteins, or genetic manipulation of cellular networks. With Accura-3D, we created a first-in-class solution that can directly access the complex cytoarchitecture of 3D tissues and brain organoids," he added.