The market for proprotein convertase subtilisin/kexin type 9 inhibitors to lower cholesterol is taking off with several new drugs being introduced or nearing the market, which will increase competition and enable more patients to reach low-density lipoprotein goals, experts said.
"This large reduction resulted in more than 90% of patients reaching the new lower LDL targets set in recent guidelines of less than 55 mg/dL for patients with cardiovascular disease or at very high risk, and less than 70 mg/dL in patients at risk," said Stein., has also shown reductions in LDL cholesterol levels of more than 60% in patients at high risk for cardiovascular disease on maximally tolerated statins.
Despite the crowded field, there appears to be plenty of room in the market."Last year, growth was just under 40%. The first quarter of this year, it has increased by 44%. While the introduction of inclisiran has added to this growth, it hasn't dented the sales of the existing monoclonal antibodies," said Stein.
Jorge Plutzky, MD, director of preventive cardiology at Brigham and Women's Hospital in Boston, said he welcomes the prospect of new approaches to PCSK9 inhibition. Lerodalcibep's once-monthly dosing schedule and the lack of need for refrigeration may be appreciated by some patients, he said, particularly those who need to travel for long periods.
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