After decades of work, the only approved malaria vaccine, Mosquirix, made by British drug-maker GSK, was recently endorsed by the World Health Organisation .
In contrast, GSK has committed to produce up to 15 million doses of Mosquirix every year through 2028, well under than the roughly 100 million doses a year of the four-dose vaccine the WHO says is needed long-term to cover around 25 million children. Vaccine effectiveness was 80% in the group that received a higher dose of the immune-boosting adjuvant component of the vaccine, and 70% in the lower-dose adjuvant group, at 12 months following the fourth dose.The complicated structure and life cycle of the malaria parasite has long stymied efforts to develop vaccines.
Meanwhile, late-stage trial data published last year showed that if Mosquirix was administered ahead of peak malaria season in high transmission areas, it was nearly 63% effective against clinical malaria.
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